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Breast cancer leptomeningeal metastases

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Added: 04.08.2019
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Breast cancer subtypes are considered to exhibit particular patterns of metastasis, which leads to distinct survival rates following relapse 5. Previous studies have analysed the incidence and prognostic implications of LM in the following four molecular subtypes: In a cohort of 99 patients with LM, When comparing the frequency of molecular subtypes in LM with that in the whole breast cancer population, the results indicate that TN patients exhibit a higher predisposition for LM than the luminal A subtype.
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Leptomeningeal Metastases

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Leptomeningeal Metastases: Symptoms, Diagnosis, More

Multimedia Leptomeningeal metastases LM occur when cancer spreads to the membranes lining the brain and spinal cord. The leptomeninges are the membranes lining the brain and spinal cord. The cerebrospinal fluid CSF lies in between these membranes. Cancer in this location has many different names, including LM, neoplastic meningitis, and carcinomatous meningitis. Cancer cells may travel to the leptomeninges from other parts of the body via blood vessels or spread directly from the bones of the spine.
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New hope for leptomeningeal disease care

Subject groups consisted of patients consecutively referred during — A Cox proportional hazards model was used to identify factors associated with prolonged survival from LM. The Cox prognostic index was created to identify the group of patients with the most favorable prognosis. Factors beneficially affecting survival were: Based on these factors, 4 prognostic groups were found, with the most favorable group being 24 LM patients with median survival of 9.
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New hope for leptomeningeal disease care BY MD Anderson staff When cancer spreads to the central nervous system, it usually goes to the brain tissue. This type of metastasis is known as leptomeningeal disease LMD , or leptomeningeal carcinomatosis. Since leptomeningeal disease cancer cells float in the cerebrospinal fluid, they can quickly spread throughout the central nervous system. As a result, leptomeningeal disease has a poor prognosis, with survival typically measured in months.

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